Dr. Ketaki Bhate and coworkers from the University of Nottingham in the UK published in Clinical and Experimental Dermatology some interesting facts which I consider worth to share. (1)

  • There is still limited evidence about how diet, specifically diary, influences development of acne. No recommendations can be made based on scientific data at the moment. However  a healthy diet is advisable to maintain an overall health.
  • 16 studies provide evidence that acne have negative effects in quality of life, self esteem and mood in adolescents. Interestingly there is evidence that isotretinoin decreases depressive symptoms and improves quality of life.
  • The use of 2.5% benzoyl peroxide concentration seem to be sufficient and with less adverse effects.
  • Usually a combination of active ingredients seems to work better than the use of one alone.
  • Minocycline is effective in moderate to severe acne, it has a rapid onset of action however the treatment effect doesn’t last longer than other tetracyclines, and has more side effects..
  • 31 studies provide evidence that combined oral contraceptives are effective in inflammatory and noninflammatory acne.
  • There is no sufficient scientific data to explain the efficacy of chemical peels as anti-acne therapy. The most studied chemical peels are salicylic and glycolic acid peels.
  • Independent reviews suggest that benzoyl peroxide may be used as a first line of treatment in non-inflammatory acne
  • There is still no high quality scientific support for the use of spironolactone in the therapy of acne.



1. Clin Exp Dermatol. 2014;39(3):273-7

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