Propionibacterium acnes (P acnes) plays an important role in the development of acne lesions. Many of the creams we use for acne contain some component meant to kill this bacteria. However, as you might know, we have millions of bacteria in our body, some of them help us fight bad bacteria but others will actually cause problems.
French investigators have analyzed bacteria population in people with acne. They found that Staphylococcus aureus (golden Staph) may also be implicated in infecting comedones . Antibiotics used to treat acne have focused on P acnes, however we might be looking at compounds that also attack golden Staph.
What to do?
We need more research on this. However, if you are using a topical antibiotic ask your dermatologist to include also benzoyl peroxide in your routine.
Also, you can try bleach soaks. Use half milliliter, about 1/5 of teaspoon of bleach in a litter of water and apply to the face area. Be careful not to use it around the eyes and do not use it more than 3 times a week.
Dreno B, Martin R, et al. Skin microbiome and acne vulgaris: Staphylococcus, a new actor in acne. Exp Dermatol. 2017 Sep;26(9):798-803.