Propionibacterium acnes or P. acnes, is a bacteria involved in the development of acne lesions. For years topical antibiotics such as erythromycin or clindamycin have been recommended as a part of acne therapy to combat this bacteria; however increased concern has risen due to the emerged resistance of P. acnes to this type of drugs.

Topical benzoyl peroxide is an alternative of topical antibiotics, it is not expensive and doesn’t create resistance.¬†However some people cannot tolerate its side effects which include skin irritation, peeling, itching, and redness.

The development of topical nitric oxide may provide with an alternative to topical antibiotics. Nitric oxide is naturally synthesized by the human body in response to bacteria, it has a low propensity for resistance and it could even reduce sebum production.

Results of studies made with this component are going to be presented in the World Congress of Dermatology this year.